Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
This chapter is a comprehensive account of the medicinal chemistry of antiepileptic drugs. It provides the mechanism of drug action and detailed structureactivity relationships of the antiepileptic and related drugs and their clinical relevance to give the knowledge base for pharmacists. After a study of this chapter, students will be able to:
• Relate principles of gamma amino butyric acid (GABA) biosynthesis, storage, transport, and metabolism to the action of antiepileptic drugs.
• Define and differentiate among different types of seizures and epilepsy.
• Illustrate mechanism of action, SAR, metabolites, and clinical considerations of different classes of antiepileptic drugs including: barbiturates, hydantoins, oxazolidinediones, succinimides, amides, benzodiazepines, valproic acid and its derivatives, GABA-analogs, and miscellaneous compounds.
Keywords:
Antiepileptic drugs, Agonists and Antagonists of GABA and different Ion Channels, Clinical use of Antiepileptic Drugs, Drug Receptor Interaction, GABA, Structure Activity Relationship.
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Authors:Bentham Science Books