Natural Products in Clinical Trials

Author(s): Kaid Johar SR, Pooja Rathaur, Shraddha Bhadada and A.R Vasavada

DOI: 10.2174/9789811425769120020007

Implication of Natural Compounds for the Prevention of Ocular Diseases

Pp: 203-253 (51)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Our eyes are a window to this world and like other parts of our body are affected by various diseases and injuries. Prevalence of various ocular diseases is although very high, very few remedies are available. Diseases affecting eye and vision are on the rise particularly those associated with potentially blinding conditions such as diabetic retinopathy, age-related macular degeneration, and glaucoma. Prevention appears to be a better modality for most of the ocular diseases compared to that of the treatment options. Natural compounds have found its use in the prevention and treatment of many ocular diseases. Several natural compounds with properties such as anti-oxidative, anti-proliferative, immunomodulatory have been implicated in the prevention of various ocular diseases. However, there are many avenues left for the application of natural compounds for the prevention and treatment of various ocular diseases. Understanding of the probable mechanism responsible for the disease formation, identification of targets, evaluation of candidate molecules by in silico, in vitro and in vivo assays can strengthen the application of natural compounds for the prevention of ocular diseases. Besides disease prevention, natural compounds have also found its use in various ocular surgical procedures.

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