Frontiers in Lung Cancer

Author(s): Sean B. Knight

DOI: 10.2174/9789811459566120010004

Biology and Molecular Evolution of Lung Cancer

Pp: 21-44 (24)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Lung cancer is the worldwide leading cause of cancer-related deaths [1]. At a fundamental level, understanding the important molecular and cellular events that lead to lung cancer is critical for developing treatments to reverse this statistic. This chapter reviews the progress and limitations of our current understanding of lung cancer. It describes the initiation and progression of lung cancer from carcinogeninduced mutation of DNA to tumour formation and metastases.

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