Current Trends of Supercritical Fluid Technology in Pharmaceutical, Nutraceutical and Food Processing Industries

Author(s): A. R. Sampaio de Sousa and Catarina M. M. Duarte

DOI: 10.2174/978160805046811001010029

Particles from Gas-Saturated Solutions and Related Methods for Particle Engineering

Pp: 29-40 (12)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

One of the most promising methods for particle engineering using supercritical fluids is the PGSS – Particles from gas saturated solutions and derived methods. It has been used to micronized drugs and active compounds and to produce composite particles, mainly for pharmaceutical applications, however food applications are starting to arise among experimental work with potential for industrial applications. The morphology and size of the particles obtained is diverse depending on the system used, but they are usually in a micro-nano size range. This chapter presents an overview of the basic principles of the method, several developments that were further undertaken, and a compilation of different examples and systems.

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