Sex Steroids and Apoptosis In Skeletal Muscle: Molecular Mechanisms

Author(s): Lorena M. Milanesi

DOI: 10.2174/9789811412363119010005

Subcellular Localization Of Estrogen Receptors

Pp: 63-72 (10)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

It is well established that estrogens elicit a variety of rapid effects in many tissues in addition to their actions on gene expression in the cell nucleus after Estrogen Receptors (ERs) dimerization and DNA-binding through their EREs. In this chapter we describe tissue distribution, subcellular localization, targets and roles of classical and non-classical ERs.

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