Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
N-Glycosyl compounds, analogs of glycosides possessing an N-glycosidic linkage, have attracted much attention as synthetic targets in medicinal chemistry, due to their biological activities. In this chapter, the synthesis of non-nucleosidic Nglycosyl compounds is reviewed. The groups of molecules covered herein include Nglycosylamines/ amides, sulfonamides, hydrazines, phosphoramidates and Nglycosylamino acids, among other related derivatives. Methods for their access, based on the literature from the last 20 years, as well as their relevance as bioactive substances, are focused.
Keywords:
Biological activity, Glycals, Glycosyl azides, N-Glycosylation, NGlycosylamines, N-Glycosylhydroxylamines, N-Glycosylalkoxyamines, NGlycosylamino acids, N-Glycosylamides, N-Glycosyl trichloroacetamides, NGlycosylsulfonamides, N-Glycosylhydrazines, N-Glycosylphosphoramidates, NGlycosylimines, N-Glycosyl succinimides, O-Glycoside mimetics, Staudinger ligation, Staudinger-type reactions.
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Authors:Bentham Science Books