Male Infertility: An Integrative Manual of Western and Chinese Medicine

Author(s): Giovanna Franconi

DOI: 10.2174/9781681086637118010004

Etiology and Pathogenesis of Male Infertility

Pp: 14-41 (28)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

The causes of a reduced reproductive function (hypogonadism) may be classified according to the origin of the disease. Pre-testicular factors are due to alterations in the central regulation and the hypothalamic-pituitary-testis axis, while testicular factors (from primitive testicular alterations) manifest themselves as hypergonadotropic hypogonadism and are a major cause of azoospermia and oligozoospermia. When post-testicular factors are present, the reproductive and endocrine functions are normal but there is an obstacle to semen outflow because of occlusions, infections and inflammation of the genital tract. Genetic factors such as karyotype abnormalities, microdeletions of the Y chromosome mutations and polymorphisms are discussed extensively.

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