Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
This chapter is a brief review of the mechanistic aspects of drug action and discusses the concepts of receptors and drug receptor interactions critical for pharmacological responses of drugs. After study of this chapter, students will be able to: • Discuss about receptors from historical perspectives • Explain the mechanistic principles of drug action in light of receptors • Summarize different theories of drug action such as: - Occupancy Theory - Rate Theory - Induced-Fit Theory - Macromolecular Perturbation Theory - Occupation-Activation Theory of “Two-State” Model • Understand drug receptor interactions
Keywords:
Affinity, Agonist, Antagonist, Drug receptor interaction, Efficacy, Intrinsic activity, Partial agonist, Receptor, Theories of drug action.
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Authors:Bentham Science Books