Advances in Organic Synthesis

Author(s): Gitanjali Jindal, Navneet Kaur and Subodh Kumar

DOI: 10.2174/9781681085647118080008

Advancements in Ionic Liquids for the Formation of Morita Baylis-Hillman Adducts

Pp: 224-254 (31)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

The reactions involving the carbon-carbon bond formation are the most significant and fundamental reactions in synthetic organic chemistry. Amongst such various types of reactions, Morita Baylis-Hillman (MBH) reaction has become one of the most constructive and popular routes for the production of functionalized molecules with vast utility and prospective. This reaction involves coupling of the activated alkenes with a variety of aldehydes under catalytic influence of tertiary bicyclic amines, phosphines or ionic liquids. The present significance of this reaction is credited to the fact that it leads to one-pot atom-economical construction of carbon-carbon bonds providing multifunctional molecules. Recently, ionic liquids are most extensively used for the synthesis of adducts of this reaction. This review is presented by the purpose of summarizing the various advances in ionic liquids and their use in this reaction.

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