HPV Infections: Diagnosis, Prevention, and Treatment

Author(s): Afshin Khavari, Kimia Kardani and Azam Bolhassani

DOI: 10.2174/9781681086170118010010

Immunity against HPV-Related Cancers

Pp: 95-119 (25)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

The induction of immunotolerance of the host's immune system by the persistent infection of HPV is one of the most important mechanisms for cervical lesions. The immune system modifications induced by HPV infection include tumorassociated macrophage differentiation, a compromised cellular immune response, an abnormal imbalance between type 1 T-helper cells (Th1) and Th2 cells, regulatory T cell infiltration, and down-regulated DC activation. In this chapter, the effects of HPV and its mechanism of action will be discussed on immune system.

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