Frontiers in Biomaterials

Author(s): Nasrin Mokhtari, Hamidreza Mokhtari and Mehdi Razavi

DOI: 10.2174/9781681085364117040011

Immune Aspects of Scaffold Design

Pp: 244-255 (12)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Long-term survival of scaffolds depends on having no detrimental immune response. Designing biomaterials that are able to modulate host responses and thus support the healing process is essential for tissue remodeling. In depth understanding of immune response to the biomaterials and their transplanted cells is important since the interaction between host response and transplanted cells demonstrates the biocompatibility of the implanted scaffold. In this chapter, we mainly aim to focus on innate and adaptive immune response and wound healings processes. In detail we discuss about variables that effect on the immune responses and the current strategies for modulating.

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