Frontiers in Biomaterials

Author(s): Mahboubeh Nabavinia, Ding Weng, Yi-Nan Zhang and Wanting Niu

DOI: 10.2174/9781681085784117050009

Stem Cells and Scaffolds: Strategies for Musculoskeletal System Tissue Engineering

Pp: 131-169 (39)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Musculoskeletal system mainly includes bone, cartilage, tendon, ligament, and skeletal muscle, which supports the body and connects tissues and organs together. Musculoskeletal disorders, including degenerative diseases and trauma injuries lead to the loss of part tissue, and always accompanied with pain. With the development of biomaterials, developmental biology, nanomedicine and orthopedic therapy strategies, tissue engineering of musculoskeletal system has been well investigated in the past two decades. Many musculoskeletal tissue repair strategies have achieved success in animal models, with part of them entered clinical trials which will benefit patients in the future.

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