Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
The skin and liver are the most common organs affected by the side effects of drugs. Drug-related damage to the skin and subcutaneous tissue is presented in detail in this chapter. Benign lesions include contact dermatitis and eczematous eruptions. Severe drug-induced injuries include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), acute generalized exanthematous pustulosis, bullous dermatoses and other hypersensitivity syndromes. The specific characteristics and responsible agents of these conditions are offered in tables in this chapter, and particular types of drug-induced lesions are also presented. A significant part of the chapter focuses on the effects of targeted cancer therapies on the skin and subcutaneous tissue. Granulomas and vaccine-induced lesions are also examined.
Keywords:
Adverse drug reaction, Allergy, Antibody, Contact dermatitis, Dermatosis, DRESS syndrome, Eczema, eruption, Hyperpigmentation, Hypersensitivity, Iatrogenic, Pustulosis, Stevens-Johnson syndrome, Toxic epidermal necrolysis, Vitiligo.
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Authors:Bentham Science Books