Iatrogenic Pathology of Bone Marrow and Lymphoid Tissue

Bone marrow and lymphoid tissue can be damaged by medications or radiation and are particularly susceptible to injury in bone marrow transplant recipients. Iatrogenic bone marrow suppression is a common in-hospital complication, the therapeutic management of which is difficult. In patients with cancer, aggressive treatment usually induces bone marrow damage, but this can be prevented using specific colony-stimulating factors. Heparin-induced thrombocytopenia is a distinct lesion with unusual clinical features. Its two types of manifestation are presented in this chapter, together with other lymphoid tissue-specific iatrogenic disorders.

Keywords: Adverse drug reaction, Bone marrow, Chemotherapeutics, Iatrogenic, Infection, Lymphoid tissue, Radiation, Sepsis, Thrombocytopenia, Thrombocytosis, Thromboembolism, Thrombosis, Transplant.