Anti-Obesity Drug Discovery and Development

Author(s): Parth J. Parekh, Edward C. Oldfield, Amrit Lamba and David A. Johnson

DOI: 10.2174/9781681081878117030007

The Role of Gut Microflora in Obesity - Does the Data Provide an Option for Intervention?

Pp: 204-227 (24)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

The obesity epidemic has proven to have a significant burden on the current of state of healthcare. At an individual level, obesity and its sequelae have numerous effects on the state of health and quality of life. On a global perspective, treatment of obesity and its sequelae come at a high cost. Obesity, in terms of intestinal dysbiosis, is a complicated disequilibrium that offers many unclear complications. Thus, restoration of the commensal microflora serves a potential therapeutic option in combatting the obesity epidemic be it via antibiotic therapy, probiotics, prebiotics, symbiotics (combination of prebiotic and probiotic therapy), or fecal microbiota transplant. This manuscript will review the role of intestinal dysbiosis in the pathogenesis of obesity and the potential role for microflora manipulation as therapy.

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