New Developments in Medicinal Chemistry

Author(s): Peterson de Andrade, Lilian Sibelle Campos Bernardes and Ivone Carvalho

DOI: 10.2174/978160805127411001010114

General Aspects of the Microwave-Assisted Drug Development

Pp: 114-132 (19)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Microwaves are a powerful and reliable energy sources that may be adapted to many applications. Since the introduction of microwave-assisted organic synthesis in 1986, the use of microwave irradiation has now introduced a completely new approach to drug discovery. The efficiency of microwave flash-heating chemistry in dramatically reducing reaction times has recently fascinated many pharmaceutical companies, which are incorporating microwave chemistry into their drug development efforts. Thereby, the time saved by using microwaves is important for accelerating traditional organic synthesis or high-speed medicinal chemistry.

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