Frontiers in Arthritis

Author(s): Carmen Frias Kletecka

DOI: 10.2174/9781681083513117010006

Pathology of Osteoarthritis

Pp: 3-9 (7)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

The pathology of osteoarthritis is extremely complex and multifactorial. Recent technological advances have allowed the identification of specific genes and genetic alterations which have helped to elucidate some intricacies involved in the molecular basis of disease development and progression. Known factors and key recent discoveries in pathogenesis, plus typical gross and histologic pathologic findings are described in this chapter.

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