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Letters in Drug Design & Discovery

Author(s): Alexey Yurjevich Lukin, Tatiana Sergeevna Vedekhina and Mikhail Vassiljevich Chudinov*

DOI: 10.2174/1570180816666190221162055

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5-Nitrofuran-2-yl Thiohydrazones as Double Antibacterial Agents Synthesis and In Vitro Evaluation

Page: [356 - 361] Pages: 6

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Abstract

Background: Applying of "double-drug" strategy to 5-nitrofuran derivatives has been proposed.

Methods: A small library of 5-Nitrofuran-2-yl Thiohydrazones was developed, and initial screening demonstrated good activity against bacteria and fungi of ESKAPE panel.

Results and Conclusion: The synthesis of the desired thiohydrazones was carried out via condensation of 5-nitrofuran-2-carbaldehyde with thiohydrazides of substituted oxamic acids.

Keywords: 5-Nitrofuran derivatives, thiohydrazones, double drug, health care-associated infections, bacterial resistance, CO-ADD.

Graphical Abstract

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