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Letters in Drug Design & Discovery

Author(s): Gundala Sravya, Ummadi Nagarjuna, Venkatapuram Padmavathi, Galla Rajitha, Sakuri Chandi priya and Adivireddy Padmaja*

DOI: 10.2174/1570180816666181102114529

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Synthesis, Antioxidant and Anti-inflammatory Activities of 5-((styrylsulfonyl) methyl)-1,3,4-Oxadiazol / Thiadiazol-2-amine Derivatives

Page: [1233 - 1247] Pages: 15

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Abstract

Background: A new class of 5-(styrylsulfonylmethyl)-1,3,4-oxadiazol-2-amine and 5- (styrylsulfonylmethyl)-1,3,4-thiadiazol-2-amine derivatives were prepared by derivatization of amino function.

Methods: All the synthesized compounds were tested for antioxidant and anti-inflammatory activities.

Results: The 2-amino-3-chloro-N-(5-(4-methylstyrylsulfonylmethyl)-1,3,4-oxadiazol-2-yl)-propanamide (12b) and 3-chloro-N-(5-(4-methylstyrylsulfonylmethyl)-1,3,4-oxadiazol-2-yl)-butanamide (14b) displayed significant antioxidant activity, greater than the standard Ascorbic acid.

Conclusion: Moreover, 12b and 14b also exhibited promising anti-inflammatory activity.

Keywords: Antioxidant activity, anti-inflammatory activity, semicarbazide, thiosemicarbazide, oxadiazole, thiadiazole.

Graphical Abstract

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