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Combinatorial Chemistry & High Throughput Screening

Author(s): B. Kundu, S. K. Rastogi, R. Ahmad and A.K. Srivastava

DOI: 10.2174/1386207023330020

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Identification of Novel α-Glucosidase Inhibitors by Screening Libraries Based on N- [4-(Benzyloxy) Benzoyl] Alanine Derivatives [1]

Page: [545 - 550] Pages: 6

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Abstract

A library of 72 compounds related to N- [4-(benzyloxy) benzoyl]alanine (I) was synthesized, prepared and screened for α-glucosidase inhibitory activity. Four compounds showed potent inhibition, six compounds moderate inhibition, and 16 were weak inhibitors. One compound, N- [4-(benzyloxy) benzoyl] serine, was found to be a potent inhibitor of α-glucosidase with 100% inhibition at 1μM. This inhibitor was at least five times more potent than the lead compound I.