Combinatorial Chemistry & High Throughput Screening

Author(s): Brad O. Buckman, Ameen Ghannam, Angela Li, Meina Liang, Raju Mohan and Howard P. Ng

DOI: 10.2174/1386207024607284

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Automated Parallel Solid-Phase Synthesis of Non-Peptide CCR1 Receptor Antagonists

Page: [249 - 251] Pages: 3

  • * (Excluding Mailing and Handling)

Abstract

An automated, parallel, solid-phase synthesis and screening strategy using commercially available aryl acetic acids as starting materials has discovered novel, non-peptide CCR1 antagonists (Ki < 100 nM).

Keywords: solid-phase synthesis, ccri receptor antagonist