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Combinatorial Chemistry & High Throughput Screening

Author(s): M. G. Organ, C. E. Dixon, D. Mayhew, D. J. Parks and E. A. Arvanitis

DOI: 10.2174/1386207024607301

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The Use of a Supported Base and Strong Cation Exchange (SCX) Chromatography to Prepare a Variety of Structurally-Diverse Molecular Libraries Prepared by Solution-Phase Methods

Page: [211 - 218] Pages: 8

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Abstract

The preparation of molecular libraries of aminomethylbiaryls, allylic amines, and ethanolamines using solution-phase methodology is described. In particular, the use of a solid-supported base reagent (PTBD resin) and strong cation exchange(SCX) resin to effect ‘catch and release’ purification across these diverse libraries is highlighted.

Keywords: molecular library, solution phase method, ptbd resin, scx