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Letters in Drug Design & Discovery

Author(s): Zehra Tuğçe Gür, Fatma Sezer Şenol, Suhaib Shekfeh, İlkay Erdoğan Orhan, Erden Banoğlu and Burcu Çalişkan*

DOI: 10.2174/1570180815666180420105652

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Novel Piperazine Amides of Cinnamic Acid Derivatives as Tyrosinase Inhibitors

Page: [36 - 44] Pages: 9

  • * (Excluding Mailing and Handling)

Abstract

Background: A series of novel cinnamic acid piperazine amide derivatives has been designed and synthesized, and their biological activities were also evaluated as potential tyrosinase inhibitors.

Methods: Compounds 9, 11 and 17 showed the most potent biological activity (IC50 = 66.5, 61.1 and 66 µM, respectively). In silico docking simulation was performed to position compound 11 into the Agaricus bisporus mushroom tyrosinase’s active site to determine the putative binding interactions.

Results and Conclusion: The results indicated that compound 11 could serve as a promising lead compound for further development of potent tyrosinase inhibitors.

Keywords: Ferulic acid, cinnamic acid, piperazine, tyrosinase, docking, huntington's diseases.

Graphical Abstract

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