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Letters in Drug Design & Discovery

Author(s): Xiao Xia Liang, Cheng Xiong, Min He, Changliang He and Zhongqiong Yin

DOI: 10.2174/1570180813888160201100814

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Synthesis and Biological Evaluation of Macamides Derivatives as Potent Inhibitors of Breast Cancer Cell MCF-7

Page: [489 - 494] Pages: 6

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Abstract

A series of macamides (1-4) and their synthetic analogs (5-14) were synthesized and evaluated for in vitro inhibitory activities against breast cancer cell MCF-7. The results of bioactive assay showed that two of the macamides (compound 1 and 4) and one synthetic analog (compound 5) displayed comparable inhibitory activities against MCF-7 cell line, with IC50 values of 29.6, 36.2 and 27.2 µM, respectively.

Keywords: Macamides derivatives, inhibitory activity, MCF-7.