Abstract

A series of novel biphenyl derivatives with -aminophosphonate moiety was designed and successively synthesized through Suzuki-Miyaura and Kabachnik-Fields reaction. The structures of the target compounds were confirmed by ¹H NMR, ¹³C NMR, ³¹P NMR, IR and H MRS. The antiviral activity against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) indicated that most of the target compounds exhibited certain anti-TMV and good anti-CMV activities, respectively, in which compound 4d displayed higher anti-TMV activity and compound 4s exhibited higher anti-CMV activity than the commercial agent Ningnanmycin.

Keywords: Biphenyl derivatives, α-aminophosphonate, antiviral activity, synthesis.

Graphical Abstract