Abstract

A series of simple isatin Schiff bases were synthesized through the condensation reaction. These isatin Schiff bases were characterized by NMR and MS, and the structure was discussed. Then, the cytoprotective and anti-tumor activities of these compounds were evaluated. The results show that several compounds show protection activity on the apoptosis of PC12 cells induced by H₂O₂, which are more effective than that of (±) α-Tocophreol (VE) and isatin. Besides, some compounds also show more potent anti-tumor activity against A549 and P388 cell lines than that of isatin.

Keywords: Isatin, synthesis, schiff base, structure, cytoprotective, anti-tumor.

Graphical Abstract