Combinatorial Chemistry & High Throughput Screening

Author(s): Radislav Sedlacek and Emily Chen

DOI: 10.2174/1386207053258541

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Screening for Protease Substrate by Polyvalent Phage Display

Page: [197 - 203] Pages: 7

  • * (Excluding Mailing and Handling)

Abstract

Proteases are key regulators of many physiological and pathological processes [1,2], and are recognized as important and tractable drug candidates. Consequently, knowledge of protease substrate recognition and specificity promotes identification of biologically relevant substrates, helps elucidating a

Keywords: phage display, matrix metalloproteinases, substrate profiling