Combinatorial Chemistry & High Throughput Screening

Author(s): Zinatossadat Hossaini, Fatemeh Sheikholeslami-Farahani and Faramarz Rostami-Charati

DOI: 10.2174/1386207317666141106155038

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Green Synthesis of Phosphoryl-2-Oxo-2H-Pyran via Three Component Reaction of Trialkyl Phosphites

Page: [804 - 807] Pages: 4

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Abstract

An effective one-pot synthesis of dialkoxyphosphoryl-2-oxo-2H-pyran derivatives by three-component reaction of alky bromides and dialkyl acetylenedicarboxylates in the presence of trialkyl phosphite is described. The reactions were performed under solvent-free conditions at 50°C and neutral conditions and provided good yields of products.

Keywords: 2H-pyran, Alky bromide, dialkyl acetylenedicarboxylates, green chemistry, three-component reaction, trialkyl phosphite.