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Letters in Drug Design & Discovery

Author(s): Xiaoyun Lu, Jian Tang, Qidong You, Baojie Wan and Scott G. Franzblau

DOI: 10.2174/1570180811666140812231321

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Design, Synthesis and Antitubercular Evaluation of New 2-amino-5-(4- (benzyloxy)benzyl)thiophene-3-carboxylic Acid Derivatives. Part 3

Page: [29 - 37] Pages: 9

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Abstract

A series of 2-amino-5-(4-(benzyloxy)benzyl)thiophene-3-carboxylic acid derivatives was designed and synthesized. The derivatives were evaluated for antitubercular activity against M. tuberculosis ATCC 27294 using the Microplate Alamar Blue Assay (MABA). Among them, compound 8b exhibited the most potent activity with MIC value of 1.9 µM.

Keywords: 2-amino-5-(4-(benzyloxy)benzyl)thiophene-3-carboxylic acid derivatives, antitubercular activity, design and synthesis, MIC, microplate Alamar Blue Assay (MABA), tuberculosis.

Graphical Abstract