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Combinatorial Chemistry & High Throughput Screening

Author(s): Afsar Ali Siddiki, Vinod Kumar Bairwa and Vikas N. Telvekar

DOI: 10.2174/1386207317666140314092412

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Synthesis and Biological Evaluation of Novel N' (4-aryloxybenzylidene)- 1H-Benzimidazole-2 Carbohydrazide Derivatives as Anti-Tubercular Agents

Page: [630 - 638] Pages: 9

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Abstract

A series of structurally novel, (E)-N'-(4-aryloxybenzylidene)-1H-benzimidazole-2-carbohydrazide derivatives were synthesized by molecular hybridization technique. All these compounds were evaluated against Mycobacterium tuberculosis H37Rv strains using Resazurin Microtiter assay (REMA) method. These compounds showed good antituberculosis activity with minimum inhibitory concentration (MIC) value of the range of 1.5-25 µg/mL.

Keywords: Anti-tubercular, benzimidazole, carbohydrazide esters, triclosan, molecular hybridization.