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Letters in Drug Design & Discovery

Author(s): Erika Bálint, Mónika Kállai, Orsolya Kovács, Hedvig Bölcskei and György Keglevich

DOI: 10.2174/15701808113106660096

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O-Arylation of Iodophenols with 2-Fluorobenzaldehyde Under Microwave Conditions

Page: [114 - 120] Pages: 7

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Abstract

The arylation of 4-iodo-, 2-iodo- and 3-iodophenols with 2-fluorobenzaldehyde may be carried out in the presence of K2CO3 in DMF as the solvent under microwave conditions. The arylation of 4-iodophenole was promoted by the use of triethylbenzylammonium chloride (TEBAC) as the phase transfer catalyst. In the other model reactions, the use of TEBAC was harmful. By-products formed by isomerization and disproportionation were also detected.

Keywords: 2-Flourobenzaldehyde, Iodophenols, Arylation, Microwave, Phase transfer catalysis.