Author(s): Iara F. da Silva, Prisicila R.C. Martins, Emanuelly G. da Silva, Sabrina B. Ferreira, Vitor F. Ferreira, Karen Regina C. da Costa, Marne C. de Vasconcellos, Emerson S. Lima and Fernando de C. da Silva
Page: [1085 - 1090] Pages: 6
* (Excluding Mailing and Handling)
We report herein the results of antifungal activity of fifteen 1,2,3-triazoles against Candida albicans, Candida krusei, Candida parapsilosis, Candida kefyr, Candida tropicalis, Candida dubliniensis, Tricophyton rubrum, Microporum canis and Aspergillus niger. All of the 1,2,3-triazoles were prepared from 1,3-dipolar cyclizations between aryl azides and alkynes catalyzed by Cu(I), and several of the compounds exhibited antifungal activity with low cytotoxicity. The results demonstrated the potential and importance of developing new 1,2,3-triazoles compounds with antifungal activity.
Keywords: Antifungal activity, Aspergillus spp., Candida spp., cytotoxicity, Microporum canis, 1H-1, 2, 3-Triazoles, Tricophyton rubrum.
Download PDF Flyer