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Letters in Drug Design & Discovery

Author(s): Chen Fan, Yubin Wang, Peng Lu, Xiaojian Xue and Jinxiong She

DOI: 10.2174/15701808113106660084

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Synthesis and Biological Evaluation of Novel N-[(7-pyridin-4-yl-2, 3- dihydro-benzofuran-2-yl) Methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl) Formamide as a Potent Immunosuppressant Agent

Page: [375 - 379] Pages: 5

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Abstract

N-[(7-pyridin-4-yl-2, 3-dihydro-benzofuran-2-yl) methyl]-(4-methyl-1, 2, 3-thiadiazole-5-yl)-Formamide (1) was synthesized and its immunosuppressive activity was evaluated. The results showed it had highly immunosuppressive activity and can be studied as lead compound in the development of immunosuppressant agent.

Keywords: Formamide derivatives, Synthesis, Immunosuppressive bioactivity.