Generic placeholder image

Letters in Drug Design & Discovery

Author(s): Mohammad Sharifzadeh, Hamid Reza khademi, Ali Almasirad, Zahra rezayan, Mohsen Rezayan Ghayahbashi and Mohsen Amini

DOI: 10.2174/15701808113109990015

DownloadDownload PDF Flyer Cite As
Synthesis and Anticonvulsant Activity of Some Non-Classical Dihydropyridine Like Structures

Page: [900 - 905] Pages: 6

  • * (Excluding Mailing and Handling)

Abstract

A series of dihydropyridine analogous was synthesized and evaluated for anticonvulsant activity using PTZ animal model. The main strategies are introducing a non-classical dihydropyridine like structure as anti-seizure agent. Some compounds showed significant anticonvulsant activity in comparison with the control group.

Keywords: Seizure, Anticonvulsant, Hexahydroquinoline derivative, 1, 4-dihydropyrimidine derivative, PTZ animal model, Synthesis.