Author(s): Ratchanok Pingaew, Apilak Worachartcheewan, Veda Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat and Virapong Prachayasittikul
Page: [859 - 864] Pages: 6
* (Excluding Mailing and Handling)
Metal complexes of 8-aminoquinoline (8AQ) derivatives were reported. This study presents a series of synthesized transition metal complexes of mixed ligands 8AQ-5-iodouracils (1-3) and 8AQ-5-nitrouracil (4-6) which have been investigated for their antioxidative and cytotoxic activities, as well as, powder X-ray diffraction patterns. Ni complex of 8AQ-5-nitrouracil (6) exerted significant cytotoxicity against MOLT-3 cell and superoxide scavenging activity. The results demonstrate an application of 8AQ molecule as a potential ligand for new bioactive compounds.
Keywords: Metal complex, 8-aminoquinoline, Uracils, Antioxidant, Cytotoxicity.
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