Abstract

A series of novel fluorinated cyclic enaminone derivatives was synthesized and evaluated as potential anticonvulsants in four animal models of epilepsy, MES, ScPTZ, rotorod neurotoxicity and 6Hz assay. Phase I screening test data indicated significant anticonvulsant activity for compounds 2a, 4a, 4b, 7 and 8. Except for 2a and 4c all the above compounds showed protection with no observed neurotoxicity. Compound 8 exhibited continuous protection at four tested time in the 6 Hz assay with no overt toxicity.

Keywords: Fluorinated cyclic, anticonvulsant, benzyl, maximal electroshock Seizure, neurotoxicity, Trifluoromethyl.