Combinatorial Chemistry & High Throughput Screening

Author(s): Mojtaba Mahyari, Shabnam Shaabani, Ahmad Shaabani and Seik Weng Ng

DOI: 10.2174/13862073113169990051

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A Passerini-Type Condensation: A Carboxylic Acid-Free Approach for the Synthesis of the α-Acyloxycarboxamides

Page: [858 - 864] Pages: 7

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Abstract

A Passerini-type condensation for the synthesis of α-acyloxycarboxamides starting from simple and readily available inputs, including an isocyanide, aldehydes and water in the presence of trimethylsilyl azide as a catalyst under reflux conditions in toluene in good yields, is described.

Keywords: Isocyanide, Passerini reaction, α-acyloxycarboxamides.