Author(s): Emilian Georgescu, Florentina Georgescu, Constantin Draghici, Liliana Cristian, Marcel Mirel Popa and ">Florea Dumitrascu
Page: [851 - 857] Pages: 7
* (Excluding Mailing and Handling)
A simple, clean and rapid one-pot three component, microwave-assisted synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones and nonsymmetrical, electron deficient alkynes in 1,2-epoxybutane which acts both as solvent and acid scavenger is reported. This one-pot three component synthesis implies short reaction times being at the same time highly cost-effective and environmental friendly.
Keywords: 1, 3-dipolar cycloaddition, microwaves, multicomponent reaction, N-ylide, pyrrolo[1, 2-c]pyrimidine.
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