Medicinal Chemistry

Author(s): Chunfang Gan, Lianghua Fan, Yanmin Huang, Zhiping Liu and Jianguo Cui

DOI: 10.2174/1573406411309060008

Synthesis of Novel Ring B Abeo-sterol Derivatives and their Antiproliferative Activities

Page: [846 - 854] Pages: 9

  • * (Excluding Mailing and Handling)

Abstract

Using cholesterol, β-sitosterol, dehydroisoandrosterone and pregnenolone as starting materials, a series of 6- hydroximino analogs of ring B abeo-sterols were synthesized and characterized. The antiproliferative activity of analogs was evaluated against SGC 7901 (human gastric carcinoma), HeLa (human cervical carcinoma) and Bel 7404 (human liver carcinoma) cells. The results showed that the presence of a alkyl side chain was very important for their cytotoxicity. However, the presence of 6-hydroximino cannot increase the cytotoxicity of compounds compared with 6-hydroxy group. The information obtained from the studies may be useful for the design of novel chemotherapeutic drugs.

Keywords: B abeo-sterols, synthesis, antiproliferative activity, 6-hydroximino B-norsteroids, cytotoxicity.