Combinatorial Chemistry & High Throughput Screening

Author(s): Fatemeh Sheikholeslami-Farahani and Ashraf S. Shahvelayati

DOI: 10.2174/13862073113169990041

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Synthesis of Unsaturated α-Acyloxybenzothiazoleamides via the Passerini Three-Component Reaction

Page: [726 - 730] Pages: 5

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Abstract

4-Benzothiazol-2-ylamino-4-oxo-2-butenoic acid, prepared from reaction of 2-aminobenzothiazole and maleic anhydride, are used as an acid component in Passerini three-component reaction, under solvent-free media, to produce unsaturated α-benzothiazole acyloxyamides in good yields.

Keywords: 2-Aminobenzothiazole, maleic anhydride, passerini reaction, solvent-free media.