Abstract

This study evaluated and compares the antioxidant activity of six resveratrol analogues. The analogues 4’- Hydroxyphenyl-benzo[d]thiazole (A), p-(N,N-dimethyl)aminobenzylidene-2-aminothiophenol (B) and p-Nitrobenzylidene- 2-aminothiophenol (C) were synthesized and the antioxidant activity was evaluated using the DPPH method. A descriptive statistical analysis and ANOVA followed by the Tukey test, with the aid of software. The best antioxidant activity was demonstrated by compound C (half maximal inhibitory concentration (IC50) = 18.45µM), this compound is two times more active than resveratrol (IC50= 37.28µM). Taken together, the data presented herein suggest that these molecules might serve as potential antioxidant considering that molecular modification is an effective strategy. As such, the compounds described herein can serve as prototypes for further research and the development of novel antioxidant agents.

Keywords: Antioxidants, Chemical synthesis, Resveratrol, Statistical analysis, Structure-activity relationship, Thio-Schiff bases.