Author(s): Ravindra K. Rawal, V. R. Solomon, Yenamandra S. Prabhakar, S. B. Katti and E. De Clercq
Page: [439 - 443] Pages: 5
* (Excluding Mailing and Handling)
selected 4-thiazolidinone have been synthesized and tested as anti-HIV activity. The results of the in vitro tests showed that one of the compounds, 5, inhibited the enzyme at 0.204μM concentration with minimal toxicity to MT-4 cell. Furthermore, the QSAR studies indicated the role of PMIZ, Ovality and Total energy content of the compounds in rationalizing the activity.
Keywords: thiazolidinones, metathiazanones, anti-hiv agents, nnrtis, dicyclohexylcarbodiimide (dcc)
Download PDF Flyer