Author(s): Ahmed Kamal, Rajender, Methuku Kashi Reddy, Vangala Santhosh Reddy and Gajjela Bharath Kumar
Page: [177 - 192] Pages: 16
* (Excluding Mailing and Handling)
A series of twelve benzopyran linked pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) have been synthesized. They exhibit significant DNA-binding activity and excellent cytotoxic activity against various human cancer cell lines.
Keywords: Cytotoxicity, DNA-Binding affinity, 2, 2-Dimethyl benzopyran, Pyrrolo[2, 1-c][1, 4]benzodiazepines and Piperazine
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