Abstract

A series of 2-(5-(4-fluorophenyl)-pyrazolin-1-yl)thiazoles prepared as potential antimicrobial agents is described. The synthesis involved the reaction of 5-(4-fluorophenyl)-3-heterocycl-4,5-dihydro-1H-pyrazole-1- carbothioamides 4a,b with various hydrazonoyl chlorides 5 or phenacyl bromides 8-10. These compounds were structurally characterized. The structure of 7 was confirmed by studying the X-ray crystallographic. The antimicrobial evaluations of the newly synthesized products against broad spectrum of bacteria and fungi were performed.

Keywords: Pyrazole, Antimicrobial activity, Hydrazonoyl chlorides, Pyrazoline-1-thioamide, 2-Pyrazoline-1-ylthiazoles, X-ray, JASCO FT/IR-6100, dimethylformamide, Pseudomonas, Candida Albicans