Combinatorial Chemistry & High Throughput Screening

Author(s): Faramarz Rostami-Charati, Asadollah Hassankhani and Zinatossadat Hossaini

DOI: 10.2174/138620712803901162

Microwave-Assisted Multicomponent Reactions of Alkyl Bromides: Synthesis of Thiophene Derivatives

Page: [822 - 825] Pages: 4

  • * (Excluding Mailing and Handling)

Abstract

A series of thiophene derivatives were synthesized via one-pot multicomponent reactions of alkyl bromids, aroyl or alkanoyl isothiocyanates, 1,3-dicarbonyl compounds and secondary amins under microwave irradiation at 80 °C. Particularly valuable features of this method include high yields of products, broad substrate scope, short reaction time and straightforward procedure.

Keywords: Acetyl acetone, carbonyl compounds, dimedone, microwave conditions, thiophen.