Combinatorial Chemistry & High Throughput Screening

Author(s): Zinatossadat Hossaini, Faramarz Rostami-Charati and Seyedeh Fereshteh Hayerizadeh

DOI: 10.2174/138620712803901117

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Expeditious Microwave-Assisted Synthesis of Functionalized Oxaphosphaphenanthrenes and Chromenes via Multicomponent Reactions of Trivalent Phosphorus Nucleophiles

Page: [816 - 821] Pages: 6

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Abstract

Stable derivatives of oxaphosphaphenanthrenes were prepared by using the reactions of dialkyl acetylenedicarboxylate with 3-bromo-2-naphthol in the presence of trimethyl or triphenyl phosphite under microwave conditions at 70 °C in good yields. Under similar conditions, chromene derivatives were produced by using triethyl phosphite and dialkyl acetylenedicarboxylate in the presence of OH-acids in excellent yields

Keywords: 4-hydroxycoumarine, acetylenic compounds, chromenes, one-pot reactions, trimethyl phosphate, triphenyl phosphite.