PEG-Mediated Catalyst-Free Expeditious Synthesis of Polysubstituted Anilines and Benzenes via the Reaction of Malononitrile and β-Ketoester Derivatives in the Presence of Activated Acetylenes

Mohammad      Piltan; Loghman      Moradi; Hiwa      Salimi; Kiomars      Zargoosh; Seyed      Amir Zarei

Combinatorial Chemistry & High Throughput Screening

Author(s): Mohammad Piltan, Loghman Moradi, Hiwa Salimi, Kiomars Zargoosh and Seyed Amir Zarei

DOI: 10.2174/138620712801619195

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PEG-Mediated Catalyst-Free Expeditious Synthesis of Polysubstituted Anilines and Benzenes via the Reaction of Malononitrile and β-Ketoester Derivatives in the Presence of Activated Acetylenes

Page: [571 - 575] Pages: 5

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Abstract

Poly(ethylene glycol) (PEG) has been used as a sustainable, non-volatile, and environmentally friendly reaction solvent for synthesis of functionalized anilines and benzenes via the reaction of malononitrile and β-ketoester derivatives in the presence of activated acetylenes at 80o C. No additional solvent and catalyst are required.

Keywords: Activated acetylenes, functionalized anilines and benzenes, malononitrile, PEG, β-ketoester, green chemistry, Catalyst-Free, solvent-free techniques, Aromatic amines, cyanoanilines

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