Abstract

A new series N-substituted -2-piperidine-4-yl-2H-benzotriazole (6a-6r) have been synthesized from 4-oxopiperidine- 1-carbaxylic acid tert-butyl ester. The new compounds were screened for their antibacterial activity against Gram positive bacteria (Bacillus subtilis, Bacillus megaterium, Bacillus pumilis, Staphylococcus aurius, Enterobactor aerogens and Streptococcus pyrogens) and Gram negative bacteria (Escherichia coli, Proteus vulgaris, Proteus mirabilis and Klebsiella pneumonia). Compounds 6a, 6b, 6g, 6h, 6k, 6q and 6r showed significant anti bacterial activity. The compounds have also been screened for antifungal activity viz Candida albicance, Fusarium oxysporum, Drechslera halodes,and Colletotrichum falcatum. Compounds 6a, 6b, 6d, 6g, 6h and 6r showed significant antifungal activity.

Keywords: broad spectrum activity, antiseptic, anticoagulant agent, bio active heterocyclic molecules, stock solution, anti-acetyl cholinesterase, antibacterial activities, Staph. Aurius, K2CO3-acetonitrile, Klebsiella pneumonia