Letters in Drug Design & Discovery

Author(s): Cheng-Xia Tan, Yan-Xia Shi, Jian-Quan Weng, Xing-Hai Liu, Bao-Ju Li, Wei-Guang Zhao

DOI: 10.2174/157018012799859954

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Synthesis and Antifungal Activity of 1,2,4-triazole Derivatives Containing Cyclopropane Moiety

Page: [431 - 435] Pages: 5

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Abstract

A new series of 1,2,4-triazoles containing cyclopropane moiety were synthesized and characterized by 1H NMR and elemental analyses. The biological activities results showed that most of them exhibited significant fungicidal activity towards six test fungi. Among them, several showed superiority over the commercial fungicide during the present study.

Keywords: 1, 2, 4-triazole, Cyclopropane, Antifungal activity, Synthesis, Microwave irradiation, Ultrasonic irradiation