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Drug Metabolism Letters

Author(s): Richard A. Peterson, David L. Krull, H. Roger Brown and Mark de Serres

DOI: 10.2174/187231210791698456

Cite As
Morphologic Characterization of PhoenixBio® (uPA+/+/SCID) Humanized Liver Chimeric Mouse Model

Page: [180 - 184] Pages: 5

  • * (Excluding Mailing and Handling)

Abstract

Morphological evaluation of humanized chimeric mouse livers from the PhoenixBio® (uPA+/+/SCID) mouse model show robust replacement and expansion with human hepatocytes, however areas of human hepatocytes had prominent steatosis and a variable lack of sinusoids which was consistent with decreased hepatocellular perfusion and lacked bile canalicular formation between human and mouse hepatocytes.

Keywords: Chimeric, drug metabolism, hepatocyte, humanized, liver, mouse